Changes

[[Image:Islet and acini.jpg|thumb|right|150px|Acini and islet of Langerhans - © RVC 2008]]

[[Image:Islet and acini.jpg|thumb|right|150px|Acini and islet of Langerhans - © RVC 2008]]

*Consists of acini, which resemble bunches of grapes.

*Consists of acini, which resemble bunches of grapes.

*Each acinus consists of a single layer of epithelial cells surrounding a lumen.

*Each acinus consists of a single layer of 40 - 50 pyramidal epithelial cells surrounding a lumen.

*The epithelial cells produce the secretion (pancreatic juice) containing enzymes, ions and water.

*The epithelial cells produce the secretion (pancreatic juice) containing enzymes, ions and water.

*The secretion drains into a duct called the intercalated duct.

**Intercalated ducts converge to make ducts of increasing diameter, which eventually form either the pancreatic or accessory duct.

*The base of the acinar cells are strongly basophilic owing to the presence of endoplasmic reticulum where there is a high concentraion of RNA. This part of the cell therefore stains darker with haematoxylin and eosin.

*The lumen of the acini drain into the intercalated duct.

**Intercalated ducts converge to make larger interlobular ducts, which in turn converge to make interlobar ducts.

***Interlobar ducts join to form either the pancreatic or the accessory duct.

**These ducts drain into the duodenum.

**These ducts drain into the duodenum.

**In some cases the pancreatic duct unites with the bile duct, and bile and pancreatic juice enter the duodenum together.

**In some cases the pancreatic duct unites with the bile duct, and bile and pancreatic juice enter the duodenum together.

===Endocrine===

===Endocrine===

==Species Differences==

==Species Differences==