Changes

*Limited array of ways in which to respond to injury

*Limited array of ways in which to respond to injury

**[[Muscles - degenerative#Degeneration|Degeneration]]

**[[Muscles Degenerative - Pathology#Degeneration|Degeneration]]

**[[Muscles - degenerative#Necrosis|Necrosis]]

**[[Muscles Degenerative - Pathology#Necrosis|Necrosis]]

**[[Muscles - normal#Regeneration|Regeneration]]

**[[Muscles - normal#Regeneration|Regeneration]]

**[[Muscles - degenerative#Atrophy|Atrophy]]

**[[Muscles Degenerative - Pathology#Atrophy|Atrophy]]

**[[Muscles - hyperplastic and neoplastic#Hypertrophy|Hypertrophy]]

**[[Muscles - hyperplastic and neoplastic#Hypertrophy|Hypertrophy]]

**If these conditions are not met (e.g. severe thermal damage) '''fibrosis''' will occur

**If these conditions are not met (e.g. severe thermal damage) '''fibrosis''' will occur

*Stages:

*Stages:

#Nuclei in [[Muscles - degenerative#Necrosis|necrotic segement]] disappear, hyalinased sarcoplasm due to loss of normal myofibrillar structure, may separate from adjacent normal myofibrils and/or [[Muscles - degenerative#Calcification|mineralise]]

#Nuclei in [[Muscles Degenerative - Pathology#Necrosis|necrotic segement]] disappear, hyalinased sarcoplasm due to loss of normal myofibrillar structure, may separate from adjacent normal myofibrils and/or [[Muscles Degenerative - Pathology#Calcification|mineralise]]

#Monocytes from capillaries -> macrophages in necrotic portion, satellite cells swell -> vesicular with prominent nucleoli -> mitosis (within 1-4 days after initial injury)

#Monocytes from capillaries -> macrophages in necrotic portion, satellite cells swell -> vesicular with prominent nucleoli -> mitosis (within 1-4 days after initial injury)

#Satellite cells move to centre

#Satellite cells move to centre

*Regeneration by '''budding'''

*Regeneration by '''budding'''

**When conditions are not optimal, disrupted sacrolemma

**When conditions are not optimal, disrupted sacrolemma

**E.g. injection of irritating substance, trauma, [[Muscles - degenerative#Ischaemia|infarction]]

**E.g. injection of irritating substance, trauma, [[Muscles Degenerative - Pathology#Ischaemia|infarction]]

**Myoblasts proliferate -> sacrolamma bulges from cut part -> club-shaped with numerous central nuclei = muscle giant cells

**Myoblasts proliferate -> sacrolamma bulges from cut part -> club-shaped with numerous central nuclei = muscle giant cells

*Monophasic lesions - all at same phase above

*Monophasic lesions - all at same phase above