Changes

===Osmotic Diuretics===

===Osmotic Diuretics===

These are compounds which are filtered but not reabsorbed.  They increase the osmolarity of the fluid and therefore hold more water in the tubules.  However they require intravenous administration.  They mainly act on sites freely permeable to water - the proximal tubule, the descending limb of the loop of henle and the collecting ducts.  However they also reduce the sodium uptake as relatively sodium concentration drops in the lumen when they are present.

These are compounds which are filtered but not reabsorbed.  They increase the osmolarity of the fluid and therefore hold more water in the tubules.  However they require intravenous administration.  They mainly act on sites freely permeable to water - [[Proximal Tubule - Anatomy & Physiology |the proximal tubule]], [[Loop Of Henle - Anatomy & Physiology#Thin descending limb|the descending limb of the loop of henle]] and [[Collecting Duct  - Anatomy & Physiology |the collecting ducts]].  However they also reduce the sodium uptake as relatively sodium concentration drops in the lumen when they are present.