Changes

*Bone marrow is also a [[Secondary Lymphoid Tissue - Anatomy & Physiology|secondary lympoid tissue]]

*Bone marrow is also a [[Secondary Lymphoid Tissue - Anatomy & Physiology|secondary lympoid tissue]]

**By mass the largest

**By mass the largest

<p>It has little involvement in the primary immune response, but the migration of [[B cell differentiation- Anatomy & Physiology#Memory cells|memory cells]] into the marrow from the [[Spleen - Anatomy & Physiology|spleen]] and [[Lymph Nodes - Anatomy & Physiology|lymph nodes]] means that during a subsequent exposure to an antigen it produces significant amounts of antibodies.</p>

<p>It has little involvement in the primary immune response, but the migration of [[B cell differentiation - WikiBlood#Memory cells|memory cells]] into the marrow from the [[Spleen - Anatomy & Physiology|spleen]] and [[Lymph Nodes - Anatomy & Physiology|lymph nodes]] means that during a subsequent exposure to an antigen it produces significant amounts of antibodies.</p>

===Others===

===Others===

*It is a significant source of antibodies as a large population of antibody-producing cells ([[B cell differentiation- Anatomy & Physiology#Plasma cells|plasma cells]]) reside in the bone marrow

*It is a significant source of antibodies as a large population of antibody-producing cells ([[B cell differentiation - WikiBlood#Plasma cells|plasma cells]]) reside in the bone marrow

*[[Macrophages - WikiBlood|Macrophages]] and dendritic cells in the marrow remove foreign substance from the blood

*[[Macrophages - WikiBlood|Macrophages]] and dendritic cells in the marrow remove foreign substance from the blood

**A process which also occurs in the [[Lymph Nodes - Anatomy & Physiology|lymph nodes]], [[Spleen - Anatomy & Physiology|spleen]] and [[Liver - Anatomy & Physiology#Functions|liver]]

**A process which also occurs in the [[Lymph Nodes - Anatomy & Physiology|lymph nodes]], [[Spleen - Anatomy & Physiology|spleen]] and [[Liver - Anatomy & Physiology#Functions|liver]]