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==Introduction==
<p>Mature [[Lymphocytes - WikiBlood#B cells|B cells]] that undergo stimulation by an antigen undergo class switching, and differentiate into either [[#Plasma cells|plasma]] or [[#Memory cells|memory]] cells. </p>
<p>Mature [[Lymphocytes - WikiBlood#B cells|B cells]] that undergo stimulation by an antigen undergo class switching, and differentiate into either [[#Plasma cells|plasma]] or [[#Memory cells|memory]] cells. </p>
<p>In the paracortex region of [[Lymph Nodes - Anatomy & Physiology|lymph nodes]] binding to MHC II and the presence of Il-4 produced by [[Lymphocytes - WikiBlood#Helper CD4+|CD4<sup>+</sup> T cells]] (Th2 type) causes [[Lymphocytes - WikiBlood#B cells|B cells]] to differentiate. Most [[Lymphocytes - WikiBlood#B cells|B cells]] become [[#Plasma cells|plasma cells]], however small number become [[#Memory cells|memory cells]] .</p>
<p>In the paracortex region of [[Lymph Nodes - Anatomy & Physiology|lymph nodes]] binding to MHC II and the presence of Il-4 produced by [[Lymphocytes - WikiBlood#Helper CD4+|CD4<sup>+</sup> T cells]] (Th2 type) causes [[Lymphocytes - WikiBlood#B cells|B cells]] to differentiate. Most [[Lymphocytes - WikiBlood#B cells|B cells]] become [[#Plasma cells|plasma cells]], however small number become [[#Memory cells|memory cells]] .</p>