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Interaction of a B-cell with antigen results in clonal expansion, as does activation by T-cells. The majority of B-cell clones mature into plasma cells. Plasma cells are found in the splenic [[Spleen - Anatomy & Physiology#Red Pulp|red pulp]], [[Lymph Nodes - Anatomy & Physiology#Lymph Nodes|lymph node medulla]] and [[Bone Marrow - Anatomy & Physiology|bone marrow]]. Plasma cells are the terminal differentiation state of B-cells. They migrate to the medullary cords where their whole function is to secrete antibody.
Interaction of a B-cell with antigen results in clonal expansion, as does activation by T-cells. The majority of B-cell clones mature into plasma cells. Plasma cells are found in the splenic [[Spleen - Anatomy & Physiology#Red Pulp|red pulp]], [[Lymph Nodes - Anatomy & Physiology#Lymph Nodes|lymph node medulla]] and [[Bone Marrow - Anatomy & Physiology|bone marrow]]. Plasma cells are the terminal differentiation state of B-cells. They migrate to the medullary cords where their whole function is to secrete antibody.
===Class switching===
===Class switching===
<p>Initially plasma cell produce IgM however this is not always the most appropriate Ig to be produced and therefore stimulation by [[Lymphocytes - WikiBlood#Helper CD4+|T cells]] and interleukins causes the plasma cells to undergo class switching to produce different classes of Ig.
<p>Initially plasma cell produce [[Immunoglobulin M - WikiBlood|IgM]] however this is not always the most appropriate Ig to be produced and therefore stimulation by [[Lymphocytes - WikiBlood#Helper CD4+|T cells]] and interleukins causes the plasma cells to undergo class switching to produce different classes of Ig.
*In mucosal B cells plasma cells CD40 interaction (with Th2 CD40L) and Il-10 stimulates class switching to IgA
*In mucosal B cells plasma cells CD40 interaction (with Th2 CD40L) and Il-10 stimulates class switching to [[Immunoglobulin A - WikiBlood|IgA]]
*[[Eosinophils - WikiBlood|Eosinophils]] produce Il-13 which promotes class switching to IgE</p>
*[[Eosinophils - WikiBlood|Eosinophils]] produce Il-13 which promotes class switching to [[Immunoglobulin E - WikiBlood|IgE]]</p>
<p>Plasma cells produced in the first immune response to an antigen are mainly of the class IgM whereas those produced from memory cells in the second immune response are mainly of the IgG class.</p>
<p>Plasma cells produced in the first immune response to an antigen are mainly of the class IgM whereas those produced from memory cells in the second immune response are mainly of the [[Immunoglobulin G - WikiBlood|IgG]] class.</p>
<p>For more information on class switching click [[Immunoglobulins - WikiBlood#Immunoglobulin Class Switching|here]]</p>
<p>For more information on class switching click [[Immunoglobulins - WikiBlood#Immunoglobulin Class Switching|here]]</p>