Changes

===2. Granulomatous===

===2. Granulomatous===

* Intense activation of T cells, [[Cytokines - WikiBlood|cytokine]] release and [[Macrophages - WikiBlood|macrophage]] activation cause necrosis of surrounding tissue, granuloma formation leading to destruction of host tissue.

* Intense activation of T cells, [[Cytokines - WikiBlood|cytokine]] release and [[Macrophages - WikiBlood|macrophage]] activation cause necrosis of surrounding tissue, granuloma formation leading to destruction of host tissue.

* Composed of epithelial cell, giant cells and macrophages in response to infection, for example:

* Composed of epithelial cell, [[Macrophages - WikiBlood#Giant cells|giant cells]] and [[Macrophages - WikiBlood|macrophage]] in response to infection, for example:

** ''Mycobacterium tubercle''

** ''Mycobacterium tubercle''

** Schistosome eggs

** Schistosome eggs