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Control of Feeding - Anatomy & Physiology (view source)
Revision as of 16:26, 3 September 2008
, 16:26, 3 September 2008no edit summary
**Synapse in submucosal plexus
**Synapse in submucosal plexus
*[[Endocrine System - Gut - Anatomy & Physiology|Gastrin]] secreted from endocrine cells in pyloric mucosa
*[[Gut - Anatomy & Physiology|Gastrin]] secreted from endocrine cells in pyloric mucosa
*Postganglionic fibres activate chief, parietal, mucous and G cells
*Postganglionic fibres activate chief, parietal, mucous and G cells
*Response to undigested materials, especially proteins
*Response to undigested materials, especially proteins
*Histamine and [[Endocrine System - Gut - Anatomy & Physiology|gastrin]] released
*Histamine and [[Gut - Anatomy & Physiology|gastrin]] released
*Negative feedback loop by sympathomimetic somatostatin released by paracrine method to inhibit [[Endocrine System - Gut - Anatomy & Physiology|gastrin]] secretion (when pH falls below 3)
*Negative feedback loop by sympathomimetic somatostatin released by paracrine method to inhibit [[Gut - Anatomy & Physiology|gastrin]] secretion (when pH falls below 3)
*Submucosal and myenteric plexuses activated in vagus reflex arcs
*Submucosal and myenteric plexuses activated in vagus reflex arcs
*A drop in pH below 4.5 causes release of secretin which inhibits parietal and chief cells and stimulate buffer release from the [[Pancreas - Anatomy & Physiology|pancreas]]
*A drop in pH below 4.5 causes release of secretin which inhibits parietal and chief cells and stimulate buffer release from the [[Pancreas - Anatomy & Physiology|pancreas]]
*Chyme causes release of secretin, [[Endocrine System - Gut - Anatomy & Physiology|GIP]] and [[Endocrine System - Gut - Anatomy & Physiology|CCK]] decreasing gastric sectreions and motility
*Chyme causes release of secretin, [[Gut - Anatomy & Physiology|GIP]] and [[Gut - Anatomy & Physiology|CCK]] decreasing gastric sectreions and motility
[[Image:Pancreatic control of secretion diagram.jpg|thumb|right|150px|Pancretic control of secretion - Copyright RVC 2008]]
[[Image:Pancreatic control of secretion diagram.jpg|thumb|right|150px|Pancretic control of secretion - Copyright RVC 2008]]
===Pancreatic===
===Pancreatic===
*[[Endocrine System - Gut - Anatomy & Physiology|CCK]], secretin and [[Endocrine System - Gut - Anatomy & Physiology|Gastrin]]
*[[Gut - Anatomy & Physiology|CCK]], secretin and [[Gut - Anatomy & Physiology|Gastrin]]
*Parasympathetic stimulation during cephalic and gastric phases
*Parasympathetic stimulation during cephalic and gastric phases
===Biliary===
===Biliary===
*[[Endocrine System - Gut - Anatomy & Physiology|CCK]] empties [[Gall Bladder - Anatomy & Physiology|gall bladder]]
*[[Gut - Anatomy & Physiology|CCK]] empties [[Gall Bladder - Anatomy & Physiology|gall bladder]]
*Secretin stimulates hydrogencarbonate ions from bile duct
*Secretin stimulates hydrogencarbonate ions from bile duct
*Succus entericus
*Succus entericus
*Secretin, [[Endocrine System - Gut - Anatomy & Physiology|GIP]] and [[Endocrine System - Gut - Anatomy & Physiology|Gastrin]]
*Secretin, [[Gut - Anatomy & Physiology|GIP]] and [[Gut - Anatomy & Physiology|Gastrin]]
*Vagal tone and parasympathomimetic reflex
*Vagal tone and parasympathomimetic reflex
==Neuroendocrine Regulation of Feeding==
==Neuroendocrine Regulation of Feeding==
*[[Endocrine System - Hypothalamus - Anatomy & Physiology|Hypothalamus]] is the critical region of feeding control
*[[Hypothalamus - Anatomy & Physiology|Hypothalamus]] is the critical region of feeding control
*Major hypothalamic nuclei involved:
*Major hypothalamic nuclei involved:
**[[Endocrine System - Hypothalamus - Anatomy & Physiology#Nuclei|Arcuate]]
**[[Hypothalamus - Anatomy & Physiology#Nuclei|Arcuate]]
**[[Endocrine System - Hypothalamus - Anatomy & Physiology#Nuclei|Ventromedial hypothalamus]]
**[[Hypothalamus - Anatomy & Physiology#Nuclei|Ventromedial hypothalamus]]
**[[Endocrine System - Hypothalamus - Anatomy & Physiology#Nuclei|Dorsomedial hypothalamus]]
**[[Hypothalamus - Anatomy & Physiology#Nuclei|Dorsomedial hypothalamus]]
**[[Endocrine System - Hypothalamus - Anatomy & Physiology#Nuclei|Lateral hypothalamus]]
**[[Hypothalamus - Anatomy & Physiology#Nuclei|Lateral hypothalamus]]
**[[Endocrine System - Hypothalamus - Anatomy & Physiology#Nuclei|Paraventricular hypothalamus]]
**[[Hypothalamus - Anatomy & Physiology#Nuclei|Paraventricular hypothalamus]]
===Gut Peptides===
===Gut Peptides===
|-
|-
| '''NPY'''
| '''NPY'''
| [[Endocrine System - Hypothalamus - Anatomy & Physiology#Nuclei|Arcuate nucleus]]
| [[Hypothalamus - Anatomy & Physiology#Nuclei|Arcuate nucleus]]
| Increases food intake
| Increases food intake
|-
|-
| '''Agrp'''
| '''Agrp'''
| [[Endocrine System - Hypothalamus - Anatomy & Physiology#Nuclei|Arcuate nucleus]]
| [[Hypothalamus - Anatomy & Physiology#Nuclei|Arcuate nucleus]]
| Increases food intake
| Increases food intake
|-
|-
| '''MCH'''
| '''MCH'''
| [[Endocrine System - Hypothalamus - Anatomy & Physiology#Nuclei|Lateral hypothalamus]]
| [[Hypothalamus - Anatomy & Physiology#Nuclei|Lateral hypothalamus]]
| Increases food intake
| Increases food intake
|-
|-
| '''Orexins'''
| '''Orexins'''
| [[Endocrine System - Hypothalamus - Anatomy & Physiology#Nuclei|Lateral hypothalamus]]
| [[Hypothalamus - Anatomy & Physiology#Nuclei|Lateral hypothalamus]]
| Increases food intake
| Increases food intake
|-
|-
| '''CART'''
| '''CART'''
| [[Endocrine System - Hypothalamus - Anatomy & Physiology#Nuclei|Arcuate nucleus]]
| [[Hypothalamus - Anatomy & Physiology#Nuclei|Arcuate nucleus]]
| Inhibits food intake
| Inhibits food intake
|-
|-
| '''α MSH'''
| '''α MSH'''
| [[Endocrine System - Hypothalamus - Anatomy & Physiology#Nuclei|Arcuate nucleus]]
| [[Hypothalamus - Anatomy & Physiology#Nuclei|Arcuate nucleus]]
| Inhibits food intake
| Inhibits food intake
|-
|-
| '''Bdnf'''
| '''Bdnf'''
| [[Endocrine System - Hypothalamus - Anatomy & Physiology#Nuclei|Ventromedial nucleus]]
| [[Hypothalamus - Anatomy & Physiology#Nuclei|Ventromedial nucleus]]
| Inhibits food intake
| Inhibits food intake
|-
|-