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Type I Hypersensitivity (view source)
Revision as of 10:14, 6 September 2008
, 10:14, 6 September 2008→Mechanism
**Steroid mediators, e.g. prostaglandins and leukotriens
**Steroid mediators, e.g. prostaglandins and leukotriens
1. Chemoattractants (attracts mainly neutrophils but also [[Eosinophils - WikiBlood|eosinophils]], [[Monocytes - WikiBlood||monocytes]] and [[Basophils - WikiBlood|basophils]] and plasma)
1. Chemoattractants (attracts mainly neutrophils but also [[Eosinophils - WikiBlood|eosinophils]], [[Monocytes - WikiBlood||monocytes]] and [[Basophils - WikiBlood|basophils]] and plasma)
2. Vasoactive and inflammatory peptides (e.g. histamine and serotonin) which causes acute contraction of smooth muscle fibres
2. Vasoactive and inflammatory peptides (e.g. histamine and serotonin) which causes acute contraction of smooth muscle fibres
*If the allergen is inhaled (locally) it can lead to bronchoconstriction.
3. Mucus production - due to the release of mast cell proteases
3. Mucus production - due to the release of mast cell proteases
4. Vasodilation (leads to redness and heat).
4. Vasodilation (leads to redness and heat).
5. Oedema (from leaky blood vessels).
5. Oedema (from leaky blood vessels).