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* The release of inflammatary [[Cytokines - WikiBlood|cytokines]] which can cause the dog to become itchy.
 
* The release of inflammatary [[Cytokines - WikiBlood|cytokines]] which can cause the dog to become itchy.
 
**Steroid mediators, e.g. prostaglandins and leukotriens
 
**Steroid mediators, e.g. prostaglandins and leukotriens
1. Chemoattractants (attracts mainly neutrophils but also [[Eosinophils - WikiBlood|eosinophils]], [[Monocytes - WikiBlood||monocytes]] and [[Basophils - WikiBlood|basophils]] and plasma)
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1. Chemoattractants (attracts mainly neutrophils but also [[Eosinophils - WikiBlood|eosinophils]], [[Monocytes - WikiBlood|monocytes]] and [[Basophils - WikiBlood|basophils]] and plasma)
    
2. Vasoactive and inflammatory peptides (e.g. histamine and serotonin) which causes acute contraction of smooth muscle fibres  
 
2. Vasoactive and inflammatory peptides (e.g. histamine and serotonin) which causes acute contraction of smooth muscle fibres  
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