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Immunodeficiencies - WikiBlood (view source)
Revision as of 15:01, 6 September 2008
, 15:01, 6 September 2008no edit summary
===Deficiencies of Innate Immunity===
===Deficiencies of Innate Immunity===
====Canine Cyclic Haematopoiesis====
*Also called '''Grey Collie Syndrome'''
*Autosomal recessive
*Insertion mutation in AP3B1 gene
*Diluted grey coat colour, stunted growth, poor wound healing
*Neutropenia every 2 weeks which lasts 3-4 days due to cyclic production of cells from bone marrow
*Recurrent infections, e.g. pyrexia, diarrhoea, gingivitis and arthritis
====Canine Leukocyte Adhesion Deficiency (CLAD)====
*Occurs in Irish Setters
*Missence mutation of -Cys-36-Ser- in CD18 molecule
**CD18 is required for neutrophil migration and phagocytosis
*Recurrent bacterial infection
*Neutrophilia (neutrophils remain in the blood and are unable to fight infection in the tissue)
====Bovine Leukocyte Adhesion Deficiency (BLAD)====
*Occurs in Holstein cattle
*Missence mutation of -Asp-128-Gly in CD18 molecule
*Recurrent infection, e.g. pneumonia
===Deficiencies of Adaptive Immunity===
===Deficiencies of Adaptive Immunity===
====Equine Severe Combined Immune Deficiency (Equine SCID)====
*Autosomal recessive
*Occurs in 2-3% of Arabian foals
*Defect in DNA-dependent protein kinase gene
**Gene codes for a DNA repair enzyme involved in V(D)J recombination for antigen receptors of lymphocytes (e.g. Ig and TCR)
*No functional B or T cells
*Foals develop infections (usually aorund 8 weeks of age as maternal antibody in colostrum wanes around this time)
*Foals usually die from bronchopneumonia
====Canine X-Linked Severe Combined Immune Deficiency (Canine SCID)====
====Selective IgA deficiency of German Shepherd Dogs====
====Immunodeficiency of Weimaraners====
====Rhinitis/Bronchopneumonia in Irish Wolfhounds====
====Pneumocystis infection in Miniature Dachshunds====
===Severe Combined Deficiency===
===Severe Combined Deficiency===
====Severe Combined Immune Deficiency(SCID)====
*No functional B or T cells
====Arthymic nude mice (no thymus)====
*No functional T cells
====Knock-out mice====
*E.g. Gene coding for CD4, CD8, IL-10 removed
==Secondary Immunodeficiency==
==Secondary Immunodeficiency==
===Viral Causes===
===Viral Causes===
====Feline Leukaemia Virus (FeLV)====
====Feline Immunodeficiency Virus (FIV)====
====Bovine Immunodeficiency Virus (BIV)====
===Toxic Causes===
===Toxic Causes===