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Immunodeficiencies - WikiBlood (view source)
Revision as of 14:59, 6 September 2008
, 14:59, 6 September 2008→Primary Immunodeficiency
*Canine Cyclic Haematopoiesis
*Canine Cyclic Haematopoiesis
**Also called '''Grey Collie Syndrome'''
**Autosomal recessive
**Insertion mutation in AP3B1 gene
**Diluted grey coat colour, stunted growth, poor wound healing
**Neutropenia every 2 weeks which lasts 3-4 days due to cyclic production of cells from bone marrow
**Recurrent infections, e.g. pyrexia, diarrhoea, gingivitis and arthritis
*Canine Leukocyte Adhesion Deficiency (CLAD)
*Canine Leukocyte Adhesion Deficiency (CLAD)
**Occurs in Irish Setters
**Missence mutation of -Cys-36-Ser- in CD18 molecule
***CD18 is required for neutrophil migration and phagocytosis
**Recurrent bacterial infection
**Neutrophilia (neutrophils remain in the blood and are unable to fight infection in the tissue)
*Bovine Leukocyte Adhesion Deficiency (BLAD)
*Bovine Leukocyte Adhesion Deficiency (BLAD)
**Occurs in Holstein cattle
**Missence mutation of -Asp-128-Gly in CD18 molecule
**Recurrent infection, e.g. pneumonia
===Deficiencies of Adaptive Immunity===
===Deficiencies of Adaptive Immunity===
*Equine & Canine Severe Combined Immune Deficiency (SCID)
*Equine Severe Combined Immune Deficiency (Equine SCID)
**Autosomal recessive
**Occurs in 2-3% of Arabian foals
**Defect in DNA-dependent protein kinase gene
***Gene codes for a DNA repair enzyme involved in V(D)J recombination for antigen receptors of lymphocytes (e.g. Ig and TCR)
**No functional B or T cells
**Foals develop infections (usually aorund 8 weeks of age as maternal antibody in colostrum wanes around this time)
**Foals usually die from bronchopneumonia
*Canine X-Linked Severe Combined Immune Deficiency (Canine SCID)
*Selective IgA deficiency of German Shepherd Dogs
*Selective IgA deficiency of German Shepherd Dogs