Changes

Jump to navigation Jump to search
Line 22: Line 22:     
*Canine Cyclic Haematopoiesis
 
*Canine Cyclic Haematopoiesis
 +
**Also called '''Grey Collie Syndrome'''
 +
**Autosomal recessive
 +
**Insertion mutation in AP3B1 gene
 +
**Diluted grey coat colour, stunted growth, poor wound healing
 +
**Neutropenia every 2 weeks which lasts 3-4 days due to cyclic production of cells from bone marrow
 +
**Recurrent infections, e.g. pyrexia, diarrhoea, gingivitis and arthritis
    
*Canine Leukocyte Adhesion Deficiency (CLAD)
 
*Canine Leukocyte Adhesion Deficiency (CLAD)
 +
**Occurs in Irish Setters
 +
**Missence mutation of -Cys-36-Ser- in CD18 molecule
 +
***CD18 is required for neutrophil migration and phagocytosis
 +
**Recurrent bacterial infection
 +
**Neutrophilia (neutrophils remain in the blood and are unable to fight infection in the tissue)
    
*Bovine Leukocyte Adhesion Deficiency (BLAD)
 
*Bovine Leukocyte Adhesion Deficiency (BLAD)
 +
**Occurs in Holstein cattle
 +
**Missence mutation of -Asp-128-Gly in CD18 molecule
 +
**Recurrent infection, e.g. pneumonia
    
===Deficiencies of Adaptive Immunity===
 
===Deficiencies of Adaptive Immunity===
   −
*Equine & Canine Severe Combined Immune Deficiency (SCID)
+
*Equine Severe Combined Immune Deficiency (Equine SCID)
 +
**Autosomal recessive
 +
**Occurs in 2-3% of Arabian foals
 +
**Defect in DNA-dependent protein kinase gene
 +
***Gene codes for a DNA repair enzyme involved in V(D)J recombination for antigen receptors of lymphocytes (e.g. Ig and TCR)
 +
**No functional B or T cells
 +
**Foals develop infections (usually aorund 8 weeks of age as maternal antibody in colostrum wanes around this time)
 +
**Foals usually die from bronchopneumonia
 +
 
 +
*Canine X-Linked Severe Combined Immune Deficiency (Canine SCID)
    
*Selective IgA deficiency of German Shepherd Dogs
 
*Selective IgA deficiency of German Shepherd Dogs
3,326

edits

Navigation menu