Changes

*The severity of the immunodeficiency depends on at which stage in development the problem occurs

*The severity of the immunodeficiency depends on at which stage in development the problem occurs

**E.g. Defects early on in development will affect the entire immune system

**E.g. Defects early on in development will affect the entire immune system

*A t cell deficiency can affect both the cell-mediated and humoral response as T cells play a central role in the immune system

*T cell deficiencies can affect both the cell-mediated and humoral response as T cells play a central role in the immune system

===Deficiencies of Innate Immunity===

===Deficiencies of Innate Immunity===