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* Leptin receptors are found in the liver, kidney, heart, skeletal muscles, pancreas, anterior pituitary gland and hypothalamus.
 
* Leptin receptors are found in the liver, kidney, heart, skeletal muscles, pancreas, anterior pituitary gland and hypothalamus.
 
* Leptin may be a signal that notifies GnRH neurons directly that nutritional status is adequate because a threshold 'fatness' has been achieved. Leptin may also signal to GnRH neurons indirectly via stimulation of neuropeptide Y, which in turn stimulates GnRH neurons.
 
* Leptin may be a signal that notifies GnRH neurons directly that nutritional status is adequate because a threshold 'fatness' has been achieved. Leptin may also signal to GnRH neurons indirectly via stimulation of neuropeptide Y, which in turn stimulates GnRH neurons.
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=== Glucose ===
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* Blood glucose stimulate glucose sensing neurons.
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* Glucose sensing neurons stimulate GnRH neurons to produce GnRH.
    
=== Blood Fatty Acids ===
 
=== Blood Fatty Acids ===
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