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| | * Thus, more LH and FSH are produced until puberty is reached. | | * Thus, more LH and FSH are produced until puberty is reached. |
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| − | == The Influence of Blood Glucose and Fatty Acids ==
| + | = The Influence of Blood Glucose and Fatty Acids = |
| | | | |
| | * There are three types of presynaptic neurons that can stimulate GnRH neurons: | | * There are three types of presynaptic neurons that can stimulate GnRH neurons: |
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| | ** Fatty acid sensitive neurons | | ** Fatty acid sensitive neurons |
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| − | === Leptin ===
| + | == Leptin == |
| | | | |
| | * Leptin is a hormonal peptide produced by adipocytes (fat cells). | | * Leptin is a hormonal peptide produced by adipocytes (fat cells). |
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| | * Leptin may be a signal that notifies GnRH neurons directly that nutritional status is adequate because a threshold 'fatness' has been achieved. Leptin may also signal to GnRH neurons indirectly via stimulation of neuropeptide Y, which in turn stimulates GnRH neurons. | | * Leptin may be a signal that notifies GnRH neurons directly that nutritional status is adequate because a threshold 'fatness' has been achieved. Leptin may also signal to GnRH neurons indirectly via stimulation of neuropeptide Y, which in turn stimulates GnRH neurons. |
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| − | === Glucose ===
| + | == Glucose == |
| | | | |
| | * Blood glucose stimulate glucose sensing neurons. | | * Blood glucose stimulate glucose sensing neurons. |
| | * Glucose sensing neurons stimulate GnRH neurons to produce GnRH. | | * Glucose sensing neurons stimulate GnRH neurons to produce GnRH. |
| | | | |
| − | === Blood Fatty Acids ===
| + | == Blood Fatty Acids == |
| | | | |
| | * Blood fatty acids stimulate neurons that in turn stimulate GnRH neurons. | | * Blood fatty acids stimulate neurons that in turn stimulate GnRH neurons. |
| | * Blood fatty acids are an indicator of nutritional status. | | * Blood fatty acids are an indicator of nutritional status. |