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Major Histocompatability Complexes (view source)
Revision as of 13:11, 9 September 2008
, 13:11, 9 September 2008→Interaction of MHC With Antigen
*** The intervening stretch of peptide folds into a helix within the groove
*** The intervening stretch of peptide folds into a helix within the groove
*** Is the target for T cell receptor recognition
*** Is the target for T cell receptor recognition
*MHC molecules have the capacity to bind to trillions of different peptides
**Adopt a flexible '''floppy''' conformation until a peptide binds
**Folds around the peptide to increase stability of the complex
**Uses a small number of anchor residues to tether the peptide allowing different sequences between anchors and different lengths of peptides to bind
==TCR-MHC Interaction==
==TCR-MHC Interaction==
[[Image:Location of Polymorphic Residues 1.jpg|thumb|right|150px|Location of Polymorphic Residues - Copyright Prof Dirk Werling DrMedVet PhD MRCVS]]
[[Image:Location of Polymorphic Residues 1.jpg|thumb|right|150px|Location of Polymorphic Residues - Copyright Prof Dirk Werling DrMedVet PhD MRCVS]]
=The Genetics of the MHC=
=The Genetics of the MHC=
* Different individuals have different critical amino acids within the MHC
* Different individuals have different critical amino acids within the MHC