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Adrenal Glands - Anatomy & Physiology (view source)
Revision as of 15:51, 11 September 2008
, 15:51, 11 September 2008→'''Glucocorticoids'''
* This leads to increased cAMP levels and the mobilization of more cholesterol and so the production of more cortisol. This is the rate limiting step and is determined by the P-450-enzyme.
* This leads to increased cAMP levels and the mobilization of more cholesterol and so the production of more cortisol. This is the rate limiting step and is determined by the P-450-enzyme.
* Cortisol then has a negative feedback effect on ACTH-RH and ACTH secretion.
* Cortisol then has a negative feedback effect on ACTH-RH and ACTH secretion.
'''Action'''
'''Action'''
* It inhibits DNA synthesis in some tissues. This along with degradation of protein results in a '''growth-inhibiting effect''' in times of stress.
* It inhibits DNA synthesis in some tissues. This along with degradation of protein results in a '''growth-inhibiting effect''' in times of stress.
* It can have '''anti-inflammatory''' effects. It inhibits the formation of prostaglandins and cytokines and reduces the ability of white blood cells being transported to an injured area. It helps keep in check inflammatory processes that could potentially cause tissue damage.
* It can have '''anti-inflammatory''' effects. It inhibits the formation of prostaglandins and cytokines and reduces the ability of white blood cells being transported to an injured area. It helps keep in check inflammatory processes that could potentially cause tissue damage.
* It is also '''immunosuppressive''' by reducing the lymphocyte numbers in circulation and reducing antibody production.
* It is also '''immunosuppressive''' by reducing the lymphocyte numbers in circulation and reducing antibody production.
==='''Adrenal Medulla'''===
===='''Androgens'''====
===='''Androgens'''====