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Oestrous Cycle Pharmacological Manipulation - Anatomy & Physiology (view source)
Revision as of 12:11, 12 September 2008
, 12:11, 12 September 2008→Prostaglandins
=== Prostaglandins ===
=== Prostaglandins ===
* The length of the interoestrus interval in most domestic species is controlled by the duration of the lifespan of the corpus luteum.
* Administration of PGF2α or its analogues will cause premature luteolysis of the corpus luteum.
* This can be used to manipulate the normal pattern of cyclic activity.
* The corpora lutea of the cow, mare, sow, ewe and goat respond to administration of exogenous prostaglandins.
* In the cow, mare, ewe and goat the new developing corpus luteum is refractory to prostaglandins for 3-5 days after ovulation.
* At the end of the cycle, the corpus luteum is unaffected by exogenous prostaglandin because it is already regressing under the influence of its own endogenous luteolytic hormones.
* The corpus luteum is resonsive for:
** Cow: 13 days
** Goat: 13 days
** Mare: 10 days
** Ewe: 9 days
* In the sow, the corpus luteum is refractory for up to 11 days after ovulation. It is only resposive for a period of 7-8 days.
* In the bitch and queen, corpora lutea are unresponsive to exogenous prostaglandins unless they are given repeated doses.
* Prostaglandins will cause abortion, do not use in animals that might be pregnant!
= Manipulation of the Oestrous Cycle in Various Species =
= Manipulation of the Oestrous Cycle in Various Species =