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Skin Immunologic - Pathology (view source)
Revision as of 10:32, 11 October 2008
, 10:32, 11 October 2008→Hypersensitivity reactions
==Hypersensitivity reactions==
==Hypersensitivity reactions==
===Allergic contact dermatitis===
*Usually involves [[Skin Immunologic - Pathology#Type IV reactions|Type IV reaction]]
*Pruritic lesions with self-inflicted trauma
*At areas in contact with allergen
*Grossly:
**Erythema, papules, +/- vesicles, exudation -> crusts
**If chronic, lichenification, hyperpigmentation, alopecia
*Microscopically:
**Spongiotic superficial perivascular dermatitis
**Mononuclear cells
**If chronic, epidermal hyperplasia
**May involve [[Eosinophils - WikiBlood|eosinophils]]
===Atopy===
===Atopy===
**Mast cells, eosinophils, nonmetachromatic mononuclear cells
**Mast cells, eosinophils, nonmetachromatic mononuclear cells
**Perivascular inflammation may be involved especially in horses
**Perivascular inflammation may be involved especially in horses
===Culicoides hypersensitivity===
===Culicoides hypersensitivity===
**Possibly eosinophilic folliculitis, intraepidermal pustules and [[Skin Other - Pathology#Eosinophilic granuloma|eosinophilic granulomas]]
**Possibly eosinophilic folliculitis, intraepidermal pustules and [[Skin Other - Pathology#Eosinophilic granuloma|eosinophilic granulomas]]
===Allergic contact dermatitis===
===Flea bite hypersensitivity===
*Usually involves [[Skin Immunologic - Pathology#Type IV reactions|Type IV reaction]]
*Usually involves [[Skin Immunologic - Pathology#Type I reactions|Type I reaction]] and [[Skin Immunologic - Pathology#Type IV reactions|Type IV reaction]] and cutaneous basophil hypersensitivity
*Pruritic lesions with self-inflicted trauma
*Mainly dorsolumbosacral area involved, abdomen, caudomedial thighs, flanks, neck of cats
*Secondary trauma is self-inflicted
*Grossly:
*Grossly:
**Erythema, papules, +/- vesicles, exudation -> crusts
**Papular dermatitis
**If chronic, lichenification, hyperpigmentation, alopecia
**Secondary excoriations
**Alopecic nodule if chronic
*Microscopically:
*Microscopically:
**Spongiotic superficial perivascular dermatitis
**Hyperplastic superficial perivascular dermatitis
**Mononuclear cells
**Oedema, [[Mast Cells - WikiBlood|mast cells]], [[Basophils - WikiBlood|basophils]], [[Eosinophils - WikiBlood|eosinophils]], [[Lymphocytes - WikiBlood|lymphocytes]], histiocytes
**Fibropruritic nodules covered by hyperplastic epidermis
==Autoimmune reactions==
==Autoimmune reactions==