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Pharmacokinetics
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Revision as of 13:27, 21 October 2008
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13:27, 21 October 2008
→Physiological Variables
Line 48:
Line 48:
The ionisation of a weak acid is
The ionisation of a weak acid is
−
AH<sup>+</sup> =<sup>'''
K<sub>a</sub>
'''</sup> A<sup>-</sup> + H<sup>-</sup>
+
AH<sup>+</sup> =<sup>'''
Ka
'''</sup> A<sup>-</sup> + H<sup>-</sup>
and its dissociation constant '''pK<sub>a</sub> is given by the Henderson-Hasselbach equation:
and its dissociation constant '''pK<sub>a</sub> is given by the Henderson-Hasselbach equation:
pK<sub>a</sub> = pH + log<sub>10</sub> ([AH]/[A<sup>-</sup>)
pK<sub>a</sub> = pH + log<sub>10</sub> ([AH]/[A<sup>-</sup>)
Jtulloch
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