Changes

'''Aminopenicillins''' - Amoxycillin

'''Aminopenicillins''' - Amoxycillin

• Aminopenicillins (e.g. Amoxycillin) were also synthesised to widen the spectrum of action to include many more gram negative organisms than the natural penicillins. The aminopenicillins are still susceptible to hydrolysis by beta-lactamase enzymes.

* Broader spectrum than the above penicillins.

* Active against gram positive species except those with beta-lactamase enzymes.

* Active against many obligate anaerobes.

• Extended spectrum penicillins (e.g. Ticarcillin) have been produced to increase efficacy against some of the most difficult gram negative infections to treat, such as Pseudomonas aeruginosa.  These drugs are still susceptible to hydrolysis by beta-lactamase.

 

If a beta-lactamase inhibitor ('''Clavulanic acid''') is added to the drug formulation, the spectrum of most sub-groups is extended.

• Addition of a beta-lactamase inhibitor (Clavulanic acid) broadens the spectrum of most sub-gps.

• Addition of a beta-lactamase inhibitor (Clavulanic acid) broadens the spectrum of most sub-gps.

==Pharmacokinetic Considerations==

==Pharmacokinetic Considerations==