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New page: {{unfinished}} {{toplink |linkpage =WikiDrugs |linktext =WikiDrugs |sublink1 = Anthelmintic Drugs |subtext1 = Anthelmintic Drugs |pagetype = Drugs }} This group of drugs are derived from ...
{{unfinished}}
{{toplink
|linkpage =WikiDrugs
|linktext =WikiDrugs
|sublink1 = Anthelmintic Drugs
|subtext1 = Anthelmintic Drugs
|pagetype = Drugs
}}
This group of drugs are derived from ''Streptomyces'' species and are coded as '''3-AV''' products. They are commonly known as '''avermectins''' and '''milbemycins'''. Drugs in use include; '''ivermectin, abamectin, doramectin, moxidectin, eprinomectin''' and '''selamectin'''.
==Activity==
* They have a wide spectrum of activity. They are '''endectocides'''; active against common [[nematodes]] at all developmental stages and against many [[arthropods]].
* They are inactive against trematodes, cestodes and adult filarial worms. Though are active against migrating heart worm larvae and are used as heartworm prophylactics in cats and dogs.
* Their mode of action is by opening invertebrate specific glutamate-gated chloride channels on the post-synaptic membranes. This results in '''flaccid paralysis''' of the parasite.
==Pharmacokinetics==
==Safety==
{{toplink
|linkpage =WikiDrugs
|linktext =WikiDrugs
|sublink1 = Anthelmintic Drugs
|subtext1 = Anthelmintic Drugs
|pagetype = Drugs
}}
This group of drugs are derived from ''Streptomyces'' species and are coded as '''3-AV''' products. They are commonly known as '''avermectins''' and '''milbemycins'''. Drugs in use include; '''ivermectin, abamectin, doramectin, moxidectin, eprinomectin''' and '''selamectin'''.
==Activity==
* They have a wide spectrum of activity. They are '''endectocides'''; active against common [[nematodes]] at all developmental stages and against many [[arthropods]].
* They are inactive against trematodes, cestodes and adult filarial worms. Though are active against migrating heart worm larvae and are used as heartworm prophylactics in cats and dogs.
* Their mode of action is by opening invertebrate specific glutamate-gated chloride channels on the post-synaptic membranes. This results in '''flaccid paralysis''' of the parasite.
==Pharmacokinetics==
==Safety==