Changes

* The cells involved bind by antigen/[[MHC]] class I-TcR interaction. This allows the CTL's intracellular granules to be localised at the area of contact - the granules contain most of the molecules responsible for cytotoxicity.  

* The cells involved bind by antigen/[[MHC]] class I-TcR interaction. This allows the CTL's intracellular granules to be localised at the area of contact - the granules contain most of the molecules responsible for cytotoxicity.  

* Direct cell contact stimulates the release of the granule contents into the area of contact between the two cells. The granules contain two groups of cytotoxic molecules.

* Direct cell contact stimulates the release of the granule contents into the area of contact between the two cells. The granules contain two groups of cytotoxic molecules.

#Perforin, which is structurally related to the [[Complement|complement]] component, C9 and forms pores in the cell membrane.

#'''Perforin''', which is structurally related to the [[Complement|complement]] component, C9 and forms pores in the cell membrane.

#Granzymes, which are proteolytic enzymes that target cell nucleases and cause programmed cell death.

#'''Granzymes''', which are proteolytic enzymes that target cell nucleases and cause programmed cell death.

==T-Cell Activation==

==T-Cell Activation==