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→Mechanism of Action
NSAIDs are defined as "''agents which inhibit the formation of eicosanoids from arachidonic acid''". Prostaglandins, thromboxanes and leukotrienes are all eicosanoids which have an inflammatory-mediating action.
NSAIDs are defined as "''agents which inhibit the formation of eicosanoids from arachidonic acid''". Prostaglandins, thromboxanes and leukotrienes are all eicosanoids which have an inflammatory-mediating action.
Chemical or physical injury to cells causes induction of the enzyme phospholipase-A2 (PLA2), which converts phospholipids to arachidonate. This newly-formed arachidonic acid is then converted to cyclic endoperoxidases by the action of cyclo-oxgygenase (COX) enzymes.
==Spectrum of Activity==
==Spectrum of Activity==