Changes

==Mechanism of Action==

==Mechanism of Action==

NSAIDs are defined as "''agents which inhibit the formation of eicosanoids from arachidonic acid''". Prostaglandins, thromboxanes and leukotrienes are all eicosanoids which have an inflammatory-mediating action.

NSAIDs are defined as "''agents which inhibit the formation of eicosanoids from arachidonic acid''". Prostaglandins (PGs), thromboxanes (TXs) and leukotrienes (LTs) are all eicosanoids which have an inflammatory-mediating action.

Chemical or physical injury to cells causes induction of the enzyme phospholipase-A2 (PLA2), which converts phospholipids to arachidonate. This newly-formed arachidonic acid is then converted to cyclic endoperoxidases by the action of cyclo-oxgygenase (COX) enzymes.

Chemical or physical injury to cells causes induction of the enzyme phospholipase-A2 (PLA2), which converts phospholipids to arachidonate. This newly-formed arachidonic acid is converted by the action of cyclo-oxgygenase (COX) enzymes to cyclic endoperoxidases, which can form inflammatory mediators including PGI2, PGD2, PGE2 and TXA2.

==Spectrum of Activity==

==Spectrum of Activity==