6,502
edits
Changes
Jump to navigation
Jump to search
→Mechanism of Action
* '''OP2''': Located spinally, the main effect of OP2 activation is sedation.
* '''OP2''': Located spinally, the main effect of OP2 activation is sedation.
* '''OP3''': OP3 receptor interaction gives rise to analgesia, on a spinal and supraspinal level.
* '''OP3''': OP3 receptor interaction gives rise to analgesia, on a spinal and supraspinal level.
Following interaction with the receptor and the subsequent cascade of events, opiods exert their effects by a variety of mechanisms. Neuronal excitability is decreased, along with reductions in the release of the neurotransmitters glutamate and substance P. In this manner, transmission of nociceptive impulses is inhibited and the actions detailed above are elicited.
==Pharmacokinetic Considerations==
==Pharmacokinetic Considerations==