Changes

Medetomidine is available as a 1mg/ml solution for use in dogs and cats.It is non irritant so therefore can be administered via an intravenous, intramuscular or subcutaneous route. Intravenous administration produces the most rapid effects, and the least amount of vomiting compared to other routes of administration. When given via an intramuscular route, maximal effects are not seen until 20 minutes after administration, although some sedation may be seen as early as 5 minutes. It is a very effective premedicant reducing the MAC of inhalation agents, and can be used in combination with [[NMDA Antagonists|ketamine]] in cats to induce anaethesia.  

Medetomidine is available as a 1mg/ml solution for use in dogs and cats.It is non irritant so therefore can be administered via an intravenous, intramuscular or subcutaneous route. Intravenous administration produces the most rapid effects, and the least amount of vomiting compared to other routes of administration. When given via an intramuscular route, maximal effects are not seen until 20 minutes after administration, although some sedation may be seen as early as 5 minutes. It is a very effective premedicant reducing the MAC of inhalation agents, and can be used in combination with [[NMDA Antagonists|ketamine]] in cats to induce anaethesia.  

===Romifidine===

Romifidine is available as a 10mg/ml solution for use in horses. Its main indication for use is as a sedation agent and may be used in a premedication regime. It produces less ataxia and the head does not lower as much when compared to [[#xylazine|xylazine]] but the duration of action is longer.