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==Signalment==
==Signalment==
*Common in dogs, especially young to middle-aged dogs.
*Mixed and purebred dogs are affected but there is a familial predisposition in
**Doberman pinscher
**Bedlington Terrier
**Cocker Spaniel
**Dalmation
**Skye Terrier
**Poodle
**Labrador Retriever
**German Shepherd Dog
**Scottish Terrier
**Beagle
==Description==
==Description==
Chronic hepatitis is an inflammatory-necrotising disease of at least 6 months duration. It predominantly consists of lymphocytic-plasmacytic inflammatory infiltration. A number of causes include:
Chronic hepatitis is an inflammatory-necrotising disease of at least 6 months duration. It is characterised by hepatocellular apoptosis or necrosis, a variable mononuclear or mixed inflammatory cell infiltrate, regeneration and fibrosis (1). It predominantly consists of lymphocytic-plasmacytic inflammatory infiltration.
*Copper accumulation
*Drugs
A number of aetiologies include:
*Infections
*Familial predisposition
*Copper accumulation (copper storage disease)
*Chronic drug therapy
*Infectious for examplae infectious canine hepatitis-
*Autoimmune or steroid responsive disorder
==Diagnosis==
==Diagnosis==
===Imaging===
===Imaging===
===Biopsy===
===Histopathology===
This is required for definitive diagnosis. Histology reveals lymphoplasmacellular inflammation and necrosis of the hepatocytes adjacent to the portal tracts.
This is required for definitive diagnosis. Histology reveals lymphoplasmacellular inflammation and necrosis of the hepatocytes adjacent to the portal tracts.
==Prognosis==
==Prognosis==
==References==
*(1) Van den Ingh, TSGAM et. al. (2006). Morphological classification of parenchymal disorders of the canine and feline liver. In Rothuizen J et. al., editors: WSAVA standards for clinical and histological diagnosis of canine and feline liver disease, Oxford, England, Saunders.