Changes

The [[Female_Reproductive_Tract_-The_Uterus|uterus]] is an important site of prostaglandin synthesis.  During pregnancy, the presence of the foetus inhibits the production of prostaglandins in order to prevent luteolysis.  At parturition, an increase in prostaglandin synthesis is required.

The [[Female_Reproductive_Tract_-The_Uterus|uterus]] is an important site of prostaglandin synthesis.  During pregnancy, the presence of the foetus inhibits the production of prostaglandins in order to prevent luteolysis.  At parturition, an increase in prostaglandin synthesis is required.

* Prostaglandins are synthesized from '''arachadonic Acid''', which is derived from '''glycerophospholipids''' by the enzyme '''phospholipase A2''' (PLA2).

* Prostaglandins are synthesized from '''arachadonic acid''', which is derived from '''glycerophospholipids''' by the enzyme '''phospholipase A2''' (PLA2).

** '''Oestrogen''' liberates phospholipase A2 from lysosomes.

** '''Oestrogen''' liberates phospholipase A2 from lysosomes.

** '''Progesterone''' stabilises lysosomes, so phospholipase A2 cannot be liberated from lysosomes.

** '''Progesterone''' stabilises lysosomes, so phospholipase A2 cannot be liberated from lysosomes.