Ingestion of these substances causes the disruption of the gastric mucosal barrier. This results in increased permeability, with hydrogen ions and pepsin penetrating the mucosa. An inflammatory response subsequently occurs that may damage blood vessels, resulting in the extravasation of blood and plasma into the gastric lumen. Mucosal erosions can develop due to necrosis of the mucosal epithelial cells. | Ingestion of these substances causes the disruption of the gastric mucosal barrier. This results in increased permeability, with hydrogen ions and pepsin penetrating the mucosa. An inflammatory response subsequently occurs that may damage blood vessels, resulting in the extravasation of blood and plasma into the gastric lumen. Mucosal erosions can develop due to necrosis of the mucosal epithelial cells. |