Changes

*More common in dogs than cats

*More common in dogs than cats

*Middle-aged to older dogs

*Middle-aged to older dogs

*No sex predisposition

*No sex predilection

*Breed predisposition, more common in medium to large-breed dogs:

*Breed predisposition, more common in medium to large-breed dogs:

**Irish Setter

**Irish Setter

==Description==

==Description==

Insulinomas are well slow growing, encapsulated, functional tumours of the islet of pancreatic islet cells, which secrete insulin autonomously.  They are predominantly malignant (90% of canine isulinomas), with a high metastatic rate to regional lymph nodes, liver and omentum.

Insulinomas are well slow growing, encapsulated, functional tumours of the beta cells of the pancreatic islet cells, They secrete inaappropriately high amount of insulin irrespective of the serum glucose level.  They are predominantly malignant (90% of canine isulinomas), with a high metastatic rate to regional lymph nodes, liver and omentum.