Changes

**depression

**depression

**weight loss

**weight loss

**intermittent vomiting and diarrhoea

**intermittent [[Stomach and Abomasum Consequences of Gastric Disease - Pathology|vomiting]] and [[Intestine Diarrhoea - Pathology|diarrhoea]]

**jaundice

**[[Liver General Pathology - Pathology#Jaundice (Icterus)|jaundice]]

**lymphadenomegaly

**lymphadenomegaly

*Severe illness and pyrexia is less likely compared to [[Neutrophilic Cholangitis]].   

*Severe illness and pyrexia is less likely compared to [[Neutrophilic Cholangitis]].   

===Laboratory Tests===

===Laboratory Tests===

====Haematology====

====Haematology====

*Neutrophilia is less common than with [[Neutrophilic Cholangitis]]

*[[Changes in Inflammatory Cells Circulating in Blood - Pathology#Neutrophilia|Neutrophilia]] is less common than with [[Neutrophilic Cholangitis]]

====Biochemistry====

====Biochemistry====

===Diagnostic Imaging===

===Diagnostic Imaging===

Radiographic signs non specific.  Hepatomegaly due to enlargement of biliary ducts and in some cases ascites is also seen.

Radiographic signs non specific.  Hepatomegaly due to enlargement of [[Liver - Anatomy & Physiology#Hepatic Duct Systems|biliary ducts]] and in some cases ascites is also seen.

Ultrasonography is more helpful.  Biliary tract dilation can be seen in all cases.  Common bile duct is normally dilated and the gallbladder may also be dilated with "sludge".  Main differential is extrahepatic biliary obstruction.

Ultrasonography is more helpful.  Biliary tract dilation can be seen in all cases.  Common bile duct is normally dilated and the [[Gall Bladder - Anatomy & Physiology|gall bladder]] may also be dilated with "sludge".  Main differential is extrahepatic biliary obstruction.

===Histopathology===

===Histopathology===

Liver biopsy is important to rule out Feline Infectious Peritonitis.  It is vital to obtain a haemostasis profile prior to biopsy due to risk of prolonged coagulation with liver disease.  It is unnecessary to obtain a bile sample unless the presentation is acute, in which case [[Neutrophilic Cholangitis]] needs to be ruled out.

Liver biopsy is important to rule out Feline Infectious Peritonitis.  It is vital to obtain a haemostasis profile prior to biopsy due to risk of prolonged coagulation with liver disease.  It is unnecessary to obtain a bile sample unless the presentation is acute, in which case [[Neutrophilic Cholangitis]] needs to be ruled out.

==Treatment==

==Treatment==