− | '''Lymphocytic cholangitis''' is a slowly progressive chronic disease characterised by infiltration of the portal areas of the liver with inflammatory cells, mostly [[Lymphocytes - WikiBlood|lymphocytes]] and [[B cell differentiation - WikiBlood#Plasma cells|plasma cells]]. Bile duct hypertrophy and [[Liver General Pathology - Pathology#Fibrosis - Repair|fibrosis]] are present. However, lymphocytic cholangitis does not progress to biliary cirrhosis. An immune-mediated aetiology has been postulated but this has not been substantiated to date. It is rarely associated with pancreatitis, compared to [[Neutrophilic Cholangitis]] | + | '''Lymphocytic cholangitis''' is a slowly progressive chronic disease characterised by infiltration of the portal areas of the liver with inflammatory cells, mostly [[Lymphocytes - WikiBlood|lymphocytes]] and [[B cell differentiation - WikiBlood#Plasma cells|plasma cells]]. Bile duct hypertrophy and [[Liver General Pathology - Pathology#Fibrosis - Repair|fibrosis]] are present. However, lymphocytic cholangitis does not progress to biliary [[Liver General Pathology - Pathology#Cirrhosis|cirrhosis]]. An immune-mediated aetiology has been postulated but this has not been substantiated to date. It is rarely associated with [[Pancreatitis - WikiClinical|pancreatitis]], compared to [[Neutrophilic Cholangitis]] |