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'''Primary or idiopathic hepatic lipidosis''' is most recognised in obese indoor cats following anorexia. It is the most common hepatic disease in North America but it is also becoming more common in Europe. It is an acute hepatopathy with a large accumulation of lipid in hepatocytes, causing the liver to lose its function. The mortality rate is high unless the disease is treated aggressively. The pathogenesis includes a number of factors:
'''Primary or idiopathic hepatic lipidosis''' is most recognised in obese indoor cats following anorexia. It is the most common hepatic disease in North America but it is also becoming more common in Europe. It is an acute hepatopathy with a large accumulation of lipid in hepatocytes, causing the liver to lose its function. The mortality rate is high unless the disease is treated aggressively. The pathogenesis includes a number of factors:
*Excessive lipid mobilisation which is induced by anorexia, illness or stress.
*excessive lipid mobilisation which is induced by anorexia, illness or stress.
*Deficiency of dietary proteins and other nutrients, which reduces the liver's capacity to produce transport proteins and to metabolise fat. Recognised nutrient deficiencies include arginine, carnitine, taurine and methionine.
*deficiency of dietary proteins and other nutrients, which reduces the liver's capacity to produce transport proteins and to metabolise fat. Recognised nutrient deficiencies include arginine, carnitine, taurine and methionine.
*Disturbances in the neurohormonal control of appetite resulting in inappropriate anorexia.
*disturbances in the neurohormonal control of appetite resulting in inappropriate anorexia.
'''Secondary hepatic lipidosis''' is a neuroendocrine response in dogs and cats to other diseases for example, [[Pancreatitis - WikiClinical|pacreatitis]], diabetes mellitus, [[Inflammatory Bowel Disease - WikiClinical|inflammatory bowel disease]] and primary hyperlipidaemia. Secondary hepatic lipidosis is therefore less closely correlated with obesity and be seen in normal or even thin cats.
'''Secondary hepatic lipidosis''' is a neuroendocrine response in dogs and cats to other diseases for example, [[Pancreatitis - WikiClinical|pacreatitis]], diabetes mellitus, [[Inflammatory Bowel Disease - WikiClinical|inflammatory bowel disease]] and primary hyperlipidaemia. Secondary hepatic lipidosis is therefore less closely correlated with obesity and be seen in normal or even thin cats.