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→Pharmacokinetic Considerations
==Pharmacokinetic Considerations==
==Pharmacokinetic Considerations==
They are very lipophilic neutral small molecules, which are orally active and have a very wide volume of distribution. It is thus capable of penetrating cell membranes and will enter the CSF. It is eliminated in the liver via hepatic metabolism with only 10% being excreted in the urine unchanges. The half-life varies between each species and also with age of the animal.
They are very lipophilic neutral small molecules, which are orally active and have a very wide volume of distribution. It is thus capable of penetrating cell membranes and will enter the CSF. It is eliminated in the liver via hepatic metabolism with only 10% being excreted in the urine unchanged. The half-life varies between each species and also with age of the animal.
==Side Effects and Contraindications==
==Side Effects and Contraindications==