Changes

* If quinpyramine is used, donkeys should be well-rested beforehand, as heat, stress, and fatigue can precipitate acute  curare-like reactions after treatment

* If quinpyramine is used, donkeys should be well-rested beforehand, as heat, stress, and fatigue can precipitate acute  curare-like reactions after treatment

* <u>Once nervous signs occur, treatment for trypanosomosis is unlikely to be successful</u>, as trypanocides do not cross the blood-brain barrier

* <u>Once nervous signs occur, treatment for trypanosomosis is unlikely to be successful</u>, as trypanocides do not cross the blood-brain barrier

* [[Donkey - Euthanasia|Euthanasia]] is often recommended for dourine where there is an ongoing eradication programme, as treatment may improve clinical signs but will not sterilise the infection and the animal will remain as a carrier. A more widely applicable strategy for dourine is a combination of treatment and castration

* [[Euthanasia - Donkey|Euthanasia]] is often recommended for dourine where there is an ongoing eradication programme, as treatment may improve clinical signs but will not sterilise the infection and the animal will remain as a carrier. A more widely applicable strategy for dourine is a combination of treatment and castration

[[Image:Trypanosomosis drugs donkey.jpg|center|thumb|500px|<small><center>Drugs that have been used to treat equine trypanosomosis. (Image courtesy of  [http://drupal.thedonkeysanctuary.org.uk The Donkey Sanctuary])</center></small>]]

[[Image:Trypanosomosis drugs donkey.jpg|center|thumb|500px|<small><center>Drugs that have been used to treat equine trypanosomosis. (Image courtesy of  [http://drupal.thedonkeysanctuary.org.uk The Donkey Sanctuary])</center></small>]]