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*Histotoxic clostridia cause localised lesions in tissues and may cause toxaemia
*Histotoxic clostridia cause localised lesions in tissues and may cause toxaemia
*''C. perfringens'' cause inflammatory lesions in the gastrointestinal tract and enterotoxaemias in sheep
*''C. perfringens'' cause inflammatory lesions in the gastrointestinal tract and enterotoxaemias in sheep
===Characteristics===
===Characteristics===
*Require enriched media for growth
*Require enriched media for growth
*Produce endospores which vary in shape and location and cause bulging of mother cell
*Produce endospores which vary in shape and location and cause bulging of mother cell
===Pathogenesis and pathogenicity===
===Pathogenesis and pathogenicity===
*Exotoxins cause necrosis, haemolysis and death
*Exotoxins cause necrosis, haemolysis and death
*Collagenase, hyaluronidase and DNase enymes facilitate spread through tissues
*Collagenase, hyaluronidase and DNase enymes facilitate spread through tissues
===Diagnosis===
===Diagnosis===
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===[[Enteropathogenic and Enterotoxaemic Clostridia]]===
===[[Histotoxic Clostridia]]===
*General:
*General: