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===''C. piliforme''===
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===''[[Clostridium piliforme]]''===
 
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*Spore-forming filamentous Gram negative intracellular pathogen
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*Only grows in tissue culture or embryonated eggs
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*Causes Tyzzer's disease - severe hepatic necrosis
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*Sporadic disease in foals, calves, dogs, cats
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*Foals under 6 weeks, found dead or comatose
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*Incubation period up to 1 week
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*Depression, anorexia, fever, jaundice, diarrhoea
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*Hepatomegaly and necrosis on post mortem
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*Diagnosis: Warthin-Starry silver impregnation technique demonstrates organisms in hepatocytes
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===''C. difficile''===
 
===''C. difficile''===
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