Changes

Jump to navigation Jump to search

Yersinia (view source)

Revision as of 13:37, 12 May 2010

505 bytes removed ,  13:37, 12 May 2010
no edit summary
Line 11: Line 11:  
===Overview===
 
===Overview===
 
*Cause [[Intestine Pathogens - Pathology|intestinal disease]] in animals and are important zoonoses
 
*Cause [[Intestine Pathogens - Pathology|intestinal disease]] in animals and are important zoonoses
−
*10 species of which ''Y. pestis, Y. pseudotuberculosis and Y. enterocolitica'' are pathogenic to animals and humans; ''Y. pestis'' is the most pathogenic
+
*10 species of which [[Yersinia pestis|''Y. pestis'']], [[Yersinia pseudotuberculosis|''Y. pseudotuberculosis]] and [[Yersinia enterocolitica|''Y. enterocolitica'']] are pathogenic to animals and humans; [[Yersinia pestis|''Y. pestis'']] is the most pathogenic
−
*Rodents provide a reservoir of ''Y. pestis'', which is the cause of human plague; fleas transmit the infection to other animals and humans
+
*Rodents provide a reservoir of [[Yersinia pestis|''Y. pestis'']], which is the cause of human plague; fleas transmit the infection to other animals and humans
−
*''Y. pseudotuberculosis and Y. enterocolitica'' reside in the intestine of domestic and wild animals and birds
+
*[[Yersinia pseudotuberculosis|''Y. pseudotuberculosis'']] and [[Yersinia enterocolitica|''Y. enterocolitica'']] reside in the intestine of domestic and wild animals and birds
 
*Birds may cause mechanical transfer of the organisms
 
*Birds may cause mechanical transfer of the organisms
   Line 29: Line 29:  
===Pathogenesis===
 
===Pathogenesis===
   −
*''Y. enterocolitica and Y. pseudotuberculosis'' enter the intestinal mucosa via M cells of the Peyer's patches
+
*''Y. enterocolitica and [[Yersinia pseudotuberculosis|''Y. pseudotuberculosis'']] enter the intestinal mucosa via M cells of the Peyer's patches
 
*Engulfed by macrphages in the mucosa
 
*Engulfed by macrphages in the mucosa
 
*All three invasive species are facultative intracellular organisms and grow inside macrophages
 
*All three invasive species are facultative intracellular organisms and grow inside macrophages
Line 36: Line 36:  
*Resistant to macrophage killing mechanisms
 
*Resistant to macrophage killing mechanisms
 
*Antiphagocytic proteins secreted by the organisms interfere with host [[Neutrophils - WikiBlood|neutrophils]]
 
*Antiphagocytic proteins secreted by the organisms interfere with host [[Neutrophils - WikiBlood|neutrophils]]
−
*''Y. pestis is more invasive than the other species and also possesses and antiphagocytic capsule and a plasminogen activator which aids systemic spread; endotoxin also contributes to its pathogenicity
+
*[[Yersinia pestis|''Y. pestis'']] is more invasive than the other species and also possesses and antiphagocytic capsule and a plasminogen activator which aids systemic spread; endotoxin also contributes to its pathogenicity
 
*Transport within macrophages to mesenteric lymph nodes
 
*Transport within macrophages to mesenteric lymph nodes
 
*Replication in lymph nodes and development of necrotic lesions, with neutrophil invasion
 
*Replication in lymph nodes and development of necrotic lesions, with neutrophil invasion
Line 44: Line 44:  
===Clinical infections===
 
===Clinical infections===
   −
*''Yersinia pestis''
+
*''[[Yersinia pestis]]''
−
**Cause of bubonic plague in humans, transmitted via fleas from infected rats
+
 
−
**Not a significant veterinary disease
+
*''[[Yersinia pseudotuberculosis]]''
−
**Disease in rats and other rodents similar to the disease in humans
  −
**Bubonic form can lead to the pneumonic form, which is highly contagious and usually fatal
  −
**Humans and domestic and wild animals incidental hosts
  −
**Plague has rarely been reported in dogs, cats, camels, elephants, deer
  −
**Cats can acquire the disease from ingesting dead rodents, and show lymphadenopathy and abscesses
  −
**Fever, lethargy, swelling and abscessation of lymph nodes particularly in head and neck region
  −
**50% mortality if not treated
  −
**Possesses 3 plasmids, 2 of which are unique to this species; these encode an endotoxin, and coagulase and fibrinolytic activity
  −
*''Yersinia pseudotuberculosis''
   
**Less virulent than ''Y. pestis'' but closely related
 
**Less virulent than ''Y. pestis'' but closely related
 
**Mainly infect animals
 
**Mainly infect animals
Line 69: Line 60:  
**Granulomas occur in the gut wall and mesenteric lymph nodes
 
**Granulomas occur in the gut wall and mesenteric lymph nodes
 
**Occasional spread from the mesenteric lymph nodes to the liver and [[Spleen - Anatomy & Physiology|spleen]]
 
**Occasional spread from the mesenteric lymph nodes to the liver and [[Spleen - Anatomy & Physiology|spleen]]
−
*''Yersinia enterocolitica''
+
*''[[Yersinia enterocolitica]]''
 
**Pathogen of animals and humans
 
**Pathogen of animals and humans
 
**Found in intestinal tract and oral cavity of animals, eg. pigs, leading to infection of humans via contaminated carcasses
 
**Found in intestinal tract and oral cavity of animals, eg. pigs, leading to infection of humans via contaminated carcasses
Bara
Author, Donkey, Bureaucrats, Administrators
53,803

edits

Retrieved from "https://en.wikivet.net/Special:MobileDiff/61583"

Navigation menu