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[[Image:0051_BLISTER_DISEASE_PYTHON_ed.jpg|200px|thumb|right|'''Blister disease on a boa constrictor''' ©RVC and its licensors, Peer Zwart and Fredric Frye. All rights reserved]]

[[Image:0051_BLISTER_DISEASE_PYTHON_ed.jpg|200px|thumb|right|'''Blister disease on a boa constrictor''' (Copyright © RVC)]]

==Introduction==

==Introduction==

Vesicular dermatitis (blister disease) is associated with inappropriate environment. An overly moist environment and poor ventilation, lead to sterile skin lesions that later become infected. If left untreated septicaemia may develop in only a few days in small snakes.  

Vesicular dermatitis (blister disease) is associated with inappropriate environment. An overly moist environment and poor ventilation, lead to sterile skin lesions that later become infected. If left untreated septicaemia may develop in only a few days in small snakes.  

==Examination==

==Examination==

Natracine snakes are predisposed to developing vesicular dermatitis. History usually reveals inappropriately moist caging.  Physical examination reveals numerous blisters. If the fluid is clear, it may be sterile. If not, there may have been progression of the disease to a secondary bacterial infection.

Natracine snakes are predisposed to developing vesicular dermatitis. History usually reveals inappropriately moist caging.  Physical examination reveals numerous blisters. If the fluid is clear, it may be sterile. If not, there may have been progression of the disease to a secondary bacterial infection.

[[Image:0053_BLISTER_DISEASE_HISTO_-1_ed.jpg|200px|thumb|right|'''Histopathology of vesicular dermatitis''' ©RVC and its licensors, Peer Zwart and Fredric Frye. All rights reserved]]

[[Image:0053_BLISTER_DISEASE_HISTO_-1_ed.jpg|200px|thumb|right|'''Histopathology of vesicular dermatitis''' (Copyright © RVC)]]

==Diagnostics==

==Diagnostics==

Diagnosis of vesicular dermatitis is on history, physical examination and diagnostic aids. Initially microscopic examination of the fluid will show only a cellular exudate devoid of bacteria. Bacteriology initially may be sterile but later a variety of bacteria will be cultured. Sensitivity is essential especially if septicaemia is suspected.

Diagnosis of vesicular dermatitis is on history, physical examination and diagnostic aids. Initially microscopic examination of the fluid will show only a cellular exudate devoid of bacteria. Bacteriology initially may be sterile but later a variety of bacteria will be cultured. Sensitivity is essential especially if septicaemia is suspected.