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**[[Respiratory Viral Infections - Pathology#Infectious bovine rhinotracheitis (IBR)|'''Infectious bovine rhinotracheitis (IBR)''']]
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====Antigenicity====
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===Antigenicity===
 
*Two different viruses:
 
*Two different viruses:
**[[Respiratory Viral Infections - Pathology#Infectious bovine rhinotracheitis (IBR)|'''Infectious bovine rhinotracheitis (IBR)''']]: aerosol transfer
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**'''Infectrious Pustular Vulvovaginitis (IPV)''': venereal transfer
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[[Infectious Bovine Rhinotracheitis]]
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[[Infectious Pustular Vulvovaginitis]]
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Also known as IPV
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Caused by:[[Bovine Herpesvirus 1]]
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: venereal transfer
    
====Pathogenesis====
 
====Pathogenesis====
'''IBR''':
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*BHV-1 infects the respiratory mucosal epithelial cells (intranuclear inclusion eosinophilic inclusion bodies)from nasal mucosa down to bronchioles
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**Leading to neutrophilic inflammation of varying severity: serous -> catarrhal -> purulent nasal discharge, sneezing, coughing
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*Dypsnoea, anorexia
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*Rhinotracheitis that can develop into bronchopneumonia
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*Clinical signs include coughing, discharge, lacrimation, and increased respiratory rate
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*Clinical disease most severe in young calves - can develop mucosal ulcerative lesions in the oesophagus and forestomachs and viraemia with multiorgan infection
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*Generally high morbidity, low mortality, but up to 75% mortality if concurrent with [[Bovine Virus Diarrhoea Virus|BVDV]], caused by meningo-encephalitis
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'''IPV''':
   
*Painful genital lesions
 
*Painful genital lesions
 
*Impaired reproductive performance
 
*Impaired reproductive performance
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***ELISA for gE deletion can enable culling of carrier animals
 
***ELISA for gE deletion can enable culling of carrier animals
 
*IPV has mostly been made obsolete by AI
 
*IPV has mostly been made obsolete by AI
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[[Category:Herpesviridae]]
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