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| | ==[[:Category:Oral Cavity - Vesicular Pathology]]== | | ==[[:Category:Oral Cavity - Vesicular Pathology]]== |
| − | ===Pathology===
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| − | *Damage to [[prickle cell]]s ([[stratum spinosum]]).
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| − | *Appears as accumulation of fluid within epithelium, quickly erodes leaving hyperaemic [[stratum germinativum]].
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| − | *Heals by proliferation of new cells, so long as infection does not continue.
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| − | ===Pathogenesis===
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| − | May be caused by:
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| − | #Ingestion of hot food (corrosive liquids)
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| − | #Systemic viral diseases. e.g:
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| − | ##[[picornaviridae#Foot and Mouth Disease Virus|Foot and Mouth disease]] - ruminants and pigs
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| − | ##[[Vesicular stomatitis]] - horse, pigs, cattle
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| − | ##[[Vesicular exanthema]] - pigs
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| − | N.B. All are indistinguishable from FMD clinically.
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| − |
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| − | ===[[Foot and Mouth Disease (FMDV)]]===
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| − | ====Pathology====
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| − | =====Gross=====
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| − | #Initially - hyperaemia of mucosa (e.g. catarrhal inflammation) then within 12 hours produces fluid filled vesicles on dorsum of [[Oral Cavity - Tongue - Anatomy & Physiology|tongue]], may be other places
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| − | #Small vesicle coalesce to produce big ones -i.e. Bullae
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| − | #Very quickly rupture; epithelium appears dirty grey in colour because of necrosis - sloughed skin, very good for diagnosis
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| − | #Leave painful, hyperaemic epithelium
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| − | #Looks like "ulcer "with ragged edge but not a true ulcer as stratum germinativum retained and will rapidly heal completely in about 2 weeks unless becomes secondarily infected
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| − |
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| − | =====Microscopic lesions=====
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| − | *Degeneration of prickle cells
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| − | *Cells "balloon" as fill with fluid and then die to produce vesicle containing straw coloured or clear fluid
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| − |
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| − | ===[[Swine Vesicular Disease]]===
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| − | *May produce vesicles in mouth that are indistinguishable from foot and mouth disease
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| − | *Swine vesicular disease produces sporadic large outbreaks
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| − | **Approximately 5% have lesions in mouth, foot lesions much more common
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| − | ===Vesicles in dogs===
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| − | *Vesicles in mouth are often caused by hot food - especially in dogs.
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| − | *Can produce quite big vesicles, but will heal.
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| − | *No major problems associated with vesicles on [[Oral Cavity - Tongue - Anatomy & Physiology|tongue]] in dogs (except if due to drinking battery acid, but this also produces vomiting).
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| − |
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| | ==Catarrhal [[Stomatitis]]== | | ==Catarrhal [[Stomatitis]]== |
| | *Non-specific, general stomatitis | | *Non-specific, general stomatitis |