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Created page with '*Blistering diseases *Autoantibodies bind to desmosomal proteins -> cell adhesion disrupted -> vesicles *Types: **'''Pemphigus vulgaris''' ***Rare, severe form ***Cats and dogs *…'
*Blistering diseases
*Autoantibodies bind to desmosomal proteins -> cell adhesion disrupted -> vesicles
*Types:
**'''Pemphigus vulgaris'''
***Rare, severe form
***Cats and dogs
***Vesicles or bullae -> erosions and ulcers
***Involves oral cavity, mucocutaneous junctions and skin
***Microscopically:
****Suprabasilar vesiculation and row of basal cells adhering to basement membrane
****Superficial perivascular dermatitis
**'''Pemphigus vegetans'''
***Rare
***Dogs
***Involves the trunk
***Mild version of P. vulgaris
***Vesicopustular dermatitis + epidermal hyperplasia -> papillomatous formations
**'''Pemphigus foliaceus'''
***More common
***Cats, dogs, horses, goats
***Localised lesions or generalised
***Symmetrical vesicular or pustular dermatitis, crusts, scales, alopecia
***Microscopically:
****Acantholytic cells
****Subcorneal or intragranular pustules
****In third of equine or canine cases [[Eosinophils - WikiBlood|eosinophils]] are predominant
**'''Pemphigus erythematosus'''
***Cats and dogs
***Mild form of P. foliaceus
***Usually involves only face and external ears
*Autoantibodies bind to desmosomal proteins -> cell adhesion disrupted -> vesicles
*Types:
**'''Pemphigus vulgaris'''
***Rare, severe form
***Cats and dogs
***Vesicles or bullae -> erosions and ulcers
***Involves oral cavity, mucocutaneous junctions and skin
***Microscopically:
****Suprabasilar vesiculation and row of basal cells adhering to basement membrane
****Superficial perivascular dermatitis
**'''Pemphigus vegetans'''
***Rare
***Dogs
***Involves the trunk
***Mild version of P. vulgaris
***Vesicopustular dermatitis + epidermal hyperplasia -> papillomatous formations
**'''Pemphigus foliaceus'''
***More common
***Cats, dogs, horses, goats
***Localised lesions or generalised
***Symmetrical vesicular or pustular dermatitis, crusts, scales, alopecia
***Microscopically:
****Acantholytic cells
****Subcorneal or intragranular pustules
****In third of equine or canine cases [[Eosinophils - WikiBlood|eosinophils]] are predominant
**'''Pemphigus erythematosus'''
***Cats and dogs
***Mild form of P. foliaceus
***Usually involves only face and external ears