*Damage to [[Ameloblasts - Anatomy & Physiology|ameloblasts]] (which form [[Enamel - Anatomy & Physiology|enamel]]) in utero upsets permanent incisor formation.
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*[[Enamel - Anatomy & Physiology|Enamel]] is marked by pits, lines etc.
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====In ruminants:====
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*Damage to [[Enamel - Anatomy & Physiology|enamel]] formation most often caused by fluoride poisoning.
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*Seen in cattle grazing on pasture contaminated by cement works effluent.
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*Chalky mottling and yellow brown pitting of [[Oral Cavity - Teeth & Gingiva - Anatomy & Physiology|tooth]].
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====In canines:====
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[[Image:enamal-hypoplasia.gif|right|thumb|125px|<small>Enamal Hypoplasia Following a CDV infection (Courtesy of Alun Williams (RVC))<center></center></small>]]
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Very severe systemic disease early in life / or in utero may result in severe discoloration or pitting of [[Oral Cavity - Teeth & Gingiva - Anatomy & Physiology|teeth]] due to effect on [[Enamel - Anatomy & Physiology|enamel]] formation. (e.g. [[Paramyxoviridae#Canine Distemper Virus (CDV)|distemper in dog]])