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Created page with '*Autonomic polyganglioneuropathy in cats *Abnormal function of the sympathetic and parasympathetic system. *Whole autonomic system involved ā affected animals usually die. **Sā¦'
*Autonomic polyganglioneuropathy in cats
*Abnormal function of the sympathetic and parasympathetic system.
*Whole autonomic system involved ā affected animals usually die.
**Similar to [[Intestine Physical Disturbances - Pathology#Equine dysautonomia, or grass sickness|grass sickness]] in horses.
=====Clinical=====
*Cats show:
**Mega-oesophagus
**Dilated pupils
**Whole gut is involved (very little peristalsis)
**Constipation.
*Generalised autonomic effects:
**Reduced salivation
**Reduced lachrymation
**Bradycardia
**Constipation
**Pupillary dilatation
=====Pathology=====
*Histologically there is marked reduction in the number of neurones in all autonomic ganglia in the ventral horn of all levels of spinal cord accompanied by proliferation of non-neuronal cells.
*Similar changes in brain stem nuclei of cranial nerves.
=====Pathogenesis=====
*Acquired disease - outbreaks occurred in the past, now only occasionally seen but seems to be getting more common again.
*Possibly toxic cause.
*Possibly in dry food or in vaccine?
*Agent not really known, but produces general damage to autonomic nervous system.[[Category:Cat]]
*Abnormal function of the sympathetic and parasympathetic system.
*Whole autonomic system involved ā affected animals usually die.
**Similar to [[Intestine Physical Disturbances - Pathology#Equine dysautonomia, or grass sickness|grass sickness]] in horses.
=====Clinical=====
*Cats show:
**Mega-oesophagus
**Dilated pupils
**Whole gut is involved (very little peristalsis)
**Constipation.
*Generalised autonomic effects:
**Reduced salivation
**Reduced lachrymation
**Bradycardia
**Constipation
**Pupillary dilatation
=====Pathology=====
*Histologically there is marked reduction in the number of neurones in all autonomic ganglia in the ventral horn of all levels of spinal cord accompanied by proliferation of non-neuronal cells.
*Similar changes in brain stem nuclei of cranial nerves.
=====Pathogenesis=====
*Acquired disease - outbreaks occurred in the past, now only occasionally seen but seems to be getting more common again.
*Possibly toxic cause.
*Possibly in dry food or in vaccine?
*Agent not really known, but produces general damage to autonomic nervous system.[[Category:Cat]]