Author, Donkey, Bureaucrats, Administrators
53,803
edits
Changes
Jump to navigation
Jump to search
no edit summary
==Jaundice (Icterus)==
**dog's normal range is usually below 0.5mg/100ml
**dog's normal range is usually below 0.5mg/100ml
**level is at least 2mg/100ml when jaundice is clinically evident
**level is at least 2mg/100ml when jaundice is clinically evident
===Causes===
*overproduction of bilirubin
*overproduction of bilirubin
**eg haemolytic crises
**eg haemolytic crises
**intrahepatic biliary obstruction eg foreign bodies, tumours, or fibrosis
**intrahepatic biliary obstruction eg foreign bodies, tumours, or fibrosis
===Classification types===
====Haemolytic jaundice====
*due to increased red cell destruction
*due to increased red cell destruction
**results in increased amounts of bilirubin in the reticuloendothelial system
**results in increased amounts of bilirubin in the reticuloendothelial system
**isoimmune reactions eg newborn foal whose dam has elaborated specific antibody against its red cells
**isoimmune reactions eg newborn foal whose dam has elaborated specific antibody against its red cells
====Obstructive jaundice====
*due to bile duct obstruction
*due to bile duct obstruction
*accumulation of conjugated bilirubin
*accumulation of conjugated bilirubin
**carcinoma involving the head of the [[Pancreas - Anatomy & Physiology|pancreas]]
**carcinoma involving the head of the [[Pancreas - Anatomy & Physiology|pancreas]]
====Hepatocellular jaundice====
two factors are concerned in the production of jaundice following [[Liver - Anatomy & Physiology|liver]] cell damage
two factors are concerned in the production of jaundice following [[Liver - Anatomy & Physiology|liver]] cell damage
*damage to [[Liver - Anatomy & Physiology|liver]] cells can interfere with the passage of bile along the bile capillaries
*damage to [[Liver - Anatomy & Physiology|liver]] cells can interfere with the passage of bile along the bile capillaries
**eg intrahepatic obstruction
**eg intrahepatic obstruction
*[[Liver - Anatomy & Physiology|Liver]] cell damage may cause failure of conjugation and therefore excretion failure of bile pigment
*[[Liver - Anatomy & Physiology|Liver]] cell damage may cause failure of conjugation and therefore excretion failure of bile pigment
[[Category:Liver_-_General_Pathology]]
[[Category:Liver_-_General_Pathology]]