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Created page with '*Rare cause of chronic liver failure in young dogs *Less than 5yrs of age *Standard poodle overrepresented *Gross findings: **Micronodular microh…'
*Rare cause of chronic [[Liver - Anatomy & Physiology|liver]] failure in young dogs
*Less than 5yrs of age
*Standard poodle overrepresented
*Gross findings:
**Micronodular microhepatica, ascites, numerous portosystemic shunts
*Histology:
**Hepatic architecture disrupted by collagen and reticulin fibres separating the hepatic lobules into small clusters and individual cells
**Hepatocytes mutlifocally swollen, lightly eosinophilic, some binucleated.
**Variable nodular regeneration.
**Scattered necrotic cells and occasional foci of inflammation.
*Cu2+ accumulation not a consistent finding.
*Aetiology – possibly a specific reaction pattern in neonatal/juvenile [[Liver - Anatomy & Physiology|liver]] .
*Differentials:
**Copper toxicity
**Copper storage disease
**Aflatoxin
**Infectious diseases such as Leptospria spp. and CAV-1.
[[Category:Liver_-_Inflammatory_Pathology]][[Category:Dog]]
*Less than 5yrs of age
*Standard poodle overrepresented
*Gross findings:
**Micronodular microhepatica, ascites, numerous portosystemic shunts
*Histology:
**Hepatic architecture disrupted by collagen and reticulin fibres separating the hepatic lobules into small clusters and individual cells
**Hepatocytes mutlifocally swollen, lightly eosinophilic, some binucleated.
**Variable nodular regeneration.
**Scattered necrotic cells and occasional foci of inflammation.
*Cu2+ accumulation not a consistent finding.
*Aetiology – possibly a specific reaction pattern in neonatal/juvenile [[Liver - Anatomy & Physiology|liver]] .
*Differentials:
**Copper toxicity
**Copper storage disease
**Aflatoxin
**Infectious diseases such as Leptospria spp. and CAV-1.
[[Category:Liver_-_Inflammatory_Pathology]][[Category:Dog]]