Changes

**Bacilli appear as chains of dark blue, square-ended rods surounded with the capsule

**Bacilli appear as chains of dark blue, square-ended rods surounded with the capsule

**Extracellular toxin (holotoxin) composed of oedema factor, protective antigen and lethal factor

**Extracellular toxin (holotoxin) composed of oedema factor, protective antigen and lethal factor

**Oedema factor is an adenylate cyclase which increases intracellular cAMP concetrations, causing fluid accumulation and damaging [[Neutrophils - WikiBlood|neutrophils]]

**Oedema factor is an adenylate cyclase which increases intracellular cAMP concetrations, causing fluid accumulation and damaging [[Neutrophils|neutrophils]]

**Lethal factor causes release of cytokines from macrophages

**Lethal factor causes release of cytokines from macrophages

**Protective antigen binds to the cell receptor to allow action of the other factors

**Protective antigen binds to the cell receptor to allow action of the other factors