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Infectious Canine Hepatitis (view source)

Revision as of 15:52, 5 July 2010

443 bytes removed ,  15:52, 5 July 2010
→‎Pathogenesis
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===Pathology===
 
===Pathology===
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====Pathogenesis====
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Canine adenovirus 1 (CAV1) initially infects and replicates in the cells of the oropharynx, before establishing a viraemia. A tropism for endothelial cells exists, leading to attack of the liver sinusoids and the lining of the gall bladder. Kuppfer cells are also affected. This results in hepatitis.
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In foxes, the virus replicates in the endothelial cells of the brain resulting in neuronal damage, fits, and paralysis.
   
====Gross====
 
====Gross====
 
The liver is enlarged and friable on post-mortem examination. Extensive centrilobular necrosis leads to a pale, mottled appearance, but widespread haemorrhage is also apparent. These haemorrhages are located particularly on the serosal surface. Ascites results from this hepatitis, and fibrinous or fibrino-haemorrhagic adhesions can sometimes be seen between the lobes of the liver.
 
The liver is enlarged and friable on post-mortem examination. Extensive centrilobular necrosis leads to a pale, mottled appearance, but widespread haemorrhage is also apparent. These haemorrhages are located particularly on the serosal surface. Ascites results from this hepatitis, and fibrinous or fibrino-haemorrhagic adhesions can sometimes be seen between the lobes of the liver.
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