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→Description
==Description==
==Description==
Infectious Canine Hepatitis (ICH) is a highly contagious disease of dogs caused by [[Canine Adenovirus 1]] (CAV1).
Canine adenovirus 1 (CAV1) initially infects and replicates in the cells of the oropharynx, before establishing a viraemia. A tropism for endothelial cells exists, leading to attack of the liver sinusoids and the lining of the gall bladder. Kuppfer cells are also affected. This results in hepatitis.
In foxes, the virus replicates in the endothelial cells of the brain resulting in neuronal damage, fits, and paralysis.
==Signalment==
==Signalment==